Krikello, built at an altitude of 1,120 meters, is one of the most mountainous settlements in Central Greece. The original settlement was founded during the Byzantine period, and around 1650 it acquired a more organized form through the unification of seven scattered pastoral hamlets. Over the centuries, Krikello developed into an important agricultural and livestock-breeding center and experienced significant prosperity. During the Ottoman period, it served as the administrative and economic center of the entire vilayet of Karpenisi.
The inhabitants of Krikello played a significant role in the Greek War of Independence of 1821, reinforcing the military forces of the Gioldasaioi, Botsaris, Karaiskakis, and other chieftains. The settlement served as the capital of the former Municipality of Evrytanes from 1833 and was officially recognized as a community in 1912.
The main church of Saint Nicholas was built in 1902–1903 by craftsmen from Epirus, on the site of an earlier small church. It stands prominently at the center of the village, distinguished by its imposing and complex ground plan, as well as its stone-built façade, characteristic of most churches in Evrytania.